Research Highlights

Schaefer G*, Mosquera J-M*, Ramoner R, Park K, Romanel A, Steiner E, Horninger W, Bektic J, Ladurner-Rennau M, Rubin MA, Demichelis F*, Klocker H*.
Distinct ERG rearrangement prevalence in prostate cancer -  higher frequency in young age and in low PSA prostate cancer.
Prostate Cancer Prostatic Dis advance online publication, February 5, 2013; doi:10.1038/pcan.2013.4
http://www.nature.com/pcan/journal/vaop/ncurrent/abs/pcan20134a.html

Poptsova M, Banerjee S, Gokcumen O, Rubin MA, Demichelis F.
Impact of Constitutional Copy Number Variants on Biological Pathway Evolution.
BMC Evol Biol. 2013 Jan 23;13(1):19. [Epub ahead of print]
http://www.biomedcentral.com/1471-2148/13/19

Lin PC, Chiu YL, Banerjee S, Park K, Mosquera JM, Giannopoulou E, Alves P, Tewari AK, Gerstein MB, Beltran H, Melnick AM, Elemento O, Demichelis F, Rubin MA.
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression.
Cancer Res. 2013 Feb 1;73(3):1232-1244.
http://cancerres.aacrjournals.org/content/73/3/1232.long

Dassi E., Zuccotti P., Leo S., Provenzani A., Assfalg M., D'Onofrio M., Riva P., Quattrone A.
Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR
Nucleic Acids Research doi: 10.1093/nar/gkt017, 2013
http://nar.oxfordjournals.org/content/early/2013/01/25/nar.gkt017.abstract

Messina A., Dunleavy M., Sgadò P., Adami V., Bozzi Y., Casarosa S. (2012)
Region-specific gene expression in adult mouse CNS tissues.
Leica Science Lab website.
http://www.leica-microsystems.com/science-lab/laser-microdissection/region-specific-gene-expression-in-adult-mouse-cns-tissues/ <http://www.leica-microsystems.com/science-lab/laser-microdissection/region-specific-gene-expression-in-adult-mouse-cns-tissues/> 

Bertacchi M.,  Pandolfini L., Murenu E., Viegi A., Capsoni S., Cellerino A., Messina A., Casarosa S., Cremisi F. (2012).
The positional identity of mouse ES cells-generated neurons is affected by BMP signaling.
Mol Cell Life Sci. Oct 16. doi: 10.1007/s00018-012-1182-3.
http://download.springer.com/static/pdf/343/art%253A10.1007%252Fs00018-012-1182-3.pdf?auth66=1361259044_d10785392903d4587641cc41dde11125&ext=.pdf

Symoens F, Jousson O, Packeu A, Fratti M, Staib P, Mignon B, Monod M.
The dermatophyte species Arthroderma benhamiae: intraspecies variability and mating behaviour.
J Med Microbiol. 2012 Nov 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23180475

Latorre E, Tebaldi T, Viero G, Spartà AM, Quattrone A, Provenzani A
Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells.
Mol. Cancer 11:13, 2012
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325864

Ballarini A, Scalet G, Kos M, Cramer N, Wiehlmann L, Jousson O.
Molecular typing and epidemiological investigation of clinical populations of Pseudomonas aeruginosa using an oligonucleotide-microarray.
BMC Microbiol. 2012 Jul 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22840192
 

Segata N, Waldron L, Ballarini A, Narasimhan V, Jousson O, Huttenhower C.
Metagenomic microbial community profiling using unique clade-specific marker genes.
Nature Methods June 2012[Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22688413

Janjua H, Segata N, Bernabò P, Tamburini S, Ellen A, Jousson O.
Clinical populations of Pseudomonas aeruginosa isolated from acute infections show a high virulence range partially correlated with population structure and virulence gene expression.
Microbiology. 2012 May 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22556359

The 3D-topology of prostate cells is significantly altered in the presence of ERG overexpression.
Rickman DS, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald SY, Tripodi J, Bunting K, Najfeld V, Demichelis F, Melnick AM, Elemento O, Rubin MA.
Oncogene-Mediated Alterations in Chromatin Conformation.
Proc Natl Acad Sci U S A 2012 May 21.
http://www.ncbi.nlm.nih.gov/pubmed/22615383

Coding and non-coding inherited copy number variants were found associated with increased risk of developing prostate cancer trough a multi-institutional large scale study.
Demichelis F, Setlur SR, Banerjee S, Chakravarty D, Chen JY, Chen CX, Huang J, Beltran H, Oldridge DA, Kitabayashi N, Stenzel B, Schaefer G, Horninger W, Bektic J, Chinnaiyan AM, Goldenberg S, Siddiqui J, Regan MM, Kearney M, Soong TD, Rickman DS, Elemento O, Wei JT, Scherr DS, Sanda MA, Bartsch G, Lee C, Klocker H, Rubin MA.
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6686-91.
http://www.ncbi.nlm.nih.gov/pubmed/22496589

Ethayathulla AS, Tse PW, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H.
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6066-71.
http://www.ncbi.nlm.nih.gov/pubmed/22474346

Exome sequencing of 112 prostate adenocarcinomas may identify earlier tumorigenic drivers.
Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat J-P, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae S-S, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera J-M, Rupp N, Wild P-J, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA.
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
Nature Genetics 2012, 44:685–689.
http://www.ncbi.nlm.nih.gov/pubmed/22610119

An investigation of the molecular mechanisms regulating chemoresistance in cancer cells
Latorre E, Tebaldi T, Viero G, Spartà AM, Quattrone A, Provenzani A. Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol Cancer. 2012 Mar 21;11:13.
http://www.ncbi.nlm.nih.gov/pubmed/22436134

A review on the complexity of prostate cancer.
Barbieri CE, Demichelis F, Rubin MA. Molecular genetics of prostate cancer: emerging appreciation of genetic complexity. Histopathology. 2012 Jan;60(1):187-98.
http://www.ncbi.nlm.nih.gov/pubmed/22212086

A review on the neurodevelopmental basis of epilepsy.
Epilepsy as a neurodevelopmental disorder Bozzi Y, Casarosa S, Caleo M. Frontiers in Molecular Psychiatry, in press.

Vidalino L, Monti L, Haase A, Moro A, Acquati F, Taramelli R and Macchi P.
Intracellular trafficking of RNASET2, a novel component of P-bodies.
Biology of the Cell. 2012 Jan;104(1):13-21.
http://www.ncbi.nlm.nih.gov/pubmed/22188480

Ooi WF, Re A, Sidarovich V, Canella V, Arseni N, Adami V, Guarguaglini G, Giubettini M, Scaruffi P, Stigliani S, Lavia P, Tonini GP, Quattrone A.
Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma.
Genes Chromosomes Cancer. 2012 Feb 15. doi: 10.1002/gcc.21940. [Epub ahead of print] PubMed PMID: 22337647