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Silvio Sarubbo is a reserach fellow at CIMeC. He works with Gianpaolo Basso at the neuroimaging lab in Mattarello.
He is involved in brain surgery for lesions sited in eloquent areas and in fMRI and DTI analyses.
We study the brain functions starting from the evidences provided by pre-operative fMRI and by intra-operative direct electrical stimulation (DES) of cortical and subcortical functional areas and fibres. The main aim of our research is the definition of the plasticity phenomena of re-organization of brain networks and functions in patients who underwent to removal of brain tumours (i.e. low- and high grade Gliomas) and vascular lesions (particularly Artero-Venous Malformations and Cavernomas). We analyze and match together the pre-operative functional neuro-imaging (i.e. fMRI) and the intra-operative DES results, in order to evidence eventual functional re-arrangements over the fMRI follow-ups and a possible pattern for neural plasticity occurrence.
Finally, he is strongly interested in the study (by means of cadaveric dissections with Klingler’s technique and DTI) of human white matter in order to better define courses, anatomical relationships and functional implications of the brain fibres.
Main interests
• Brain Functions
• Brain Anatomy
• Neural Plasticity
• White Matter Connectivity
• Neurooncology
• Neuromodulation for Movement Disorders and Neuropathic Pain
Research techniques
• fMRI and DTI
• “In vivo” Brain Mapping (awake surgery)
• Cadaver dissection and Klingler’s technique
Publications (the last three years)
LIST OF PUBBLICATIONS
Introduction to neurofunctional surgery. Cavallo MA, Sarubbo S, Di Biase F. Riv Med, 14(2) 35-39, 2008.
Pallidal stimulation for segmental dystonia: long-term follow-up of 11 consecutive patients. Sensi M, Cavallo MA, Quatrale R, Sarubbo S, Biguzzi S, Lettieri C, Capone JG, Tugnoli V, Tola MR, Eleopra R. Mov Disord. 2009 Sep 15;24(12):1829-35.
Spontaneous and idiopathic chronic spinal epidural hematoma: two case reports and review of the literature. Sarubbo S, Garofano F, Maida G, Fainardi E, Granieri E, Cavallo MA. Eur Spine J. 2009 Nov;18(11):1055-61.
Potential role of CT perfusion parameters in the identification of solitary intra-axial brain tumor grading. Fainardi E, Di Biase F, Borrelli M, Saletti A, Cavallo M, Sarubbo S, Ceruti S, Tamarozzi R, Chieregato A. Acta Neurochir Suppl. 2010;106:283-7.
Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson’s Disease. Marti M, Sarubbo S, Latini F, Saletti A, Cavallo M, Eleopra R, Biguzzi S, Lettieri C, Conti C, Simonato M, Zucchini S, Quatrale R, Sensi M, Candeletti S, Romualdi P, Morari M. Mov Disord. 2010 Aug 15;25(11):1723-32.
Timing of CT perfusion abnormalities within and around spontaneous intracerebral hemorrhage during the transition from acute to subacute phases. Fainardi E, Ramponi V, Roversi G, BorrelliM, Saletti A, Bernardoni A, Sarubbo S. et al. TheNeuroradiology Journal. Vol 23, Suppl. 1, October 2010.
Awake surgery in low-grade gliomas harboring eloquent areas: three years mean follow-up. Sarubbo S, Latini F, Panajia A, Candela C, Quatrale R, Milani P; Granieri E, Trapella G, Tugnoli V, Cavallo MA. Neurol Sci. 2011 Oct;32(5):801-10. Epub 2011 Apr 13
Complete recovery after surgical resection of left Wernicke's area in awake patient: a brain stimulation and functional MRI study. Sarubbo S, Moritz-Gasser S, Le Bars E, Duffau H. Neurosurg Rev. 2011 Sep 27.
New Neuroimages and Neurosurgery. Cavallo MA, Latini F, Marcati E, Sarubbo S. Rivista Medica Vol.17, Supl. 1 Nov. 2011).
Five-year follow-up of 10 patients treated with Globus Pallidus Internus Deep Brain Stimulation for segmental or multisegmental Dystonia. S. Sarubbo, F. Latini, R. Quatrale, M. Sensi, E. Granieri, M.A. Cavallo. Stereotact Funct Neurosurg 2012;90:84-91
Spinal anesthesia and minimal invasive laminotomy for paddle electrode placement in Spinal Cord Stimulation: technical report and clinical results at long-term follow-up. S. Sarubbo, F. Latini, V. Tugnoli, R. Quatrale, E. Granieri, M. A. Cavallo. The Scientific World Journal, vol. 2012, Article ID 201053, 6 pages, 2012. DOI:10.1100/2012/201053
Subcortical surgical anatomy of the lateral frontal region: human white matter dissection and correlations with functional insights provided by intraoperative direct brain stimulation. De Benedictis A, Sarubbo S, Duffau H. - J Neurosurg. 2012 Sep 21
Temporal changes in perihematomal apparent diffusion coefficient values during the transition from acute to subacute phases in patients with spontaneous intracerebral hemorrhage. Fainardi E, Borrelli M, Saletti A, Sarubbo S, Roversi G, Bernardoni A, Latini F, Azzini C, Borgatti L, De Vito A, Cavallo M, Ceruti S, Chieregato A. - Neuroradiology. 2012 Sep 18
Is the resection of gliomas in Wernicke's area reliable? : Wernicke's area resection. Sarubbo S, Latini F, Sette E, Milani P, Granieri E, Fainardi E, Cavallo MA. Acta Neurochir (Wien). 2012 Sep;154(9):1653-62. Epub 2012 Jul 26.
BOOK CHAPTERS
Dystonia: clinical assessment and surgical treatment. Cavallo MA, Sarubbo S, Latini F. Chapter 6, Handbook of stereotactic and functional neurosurgery. Lavano A, Landi A, Lanotte MM. 2010 (ISBN: 8877116951; ISBN 13: 9788877116956) - Book Chapter
Treatment of Movement Disorders. Cavallo MA, Sarubbo S, Latini F. Chapter, Elementi di neurochirurgia. Staffa G. 2011 (ISBN: 8886891857; ISBN 13: 9788886891851) - Book Chapter
* The complete and up-dated list of scientific publications, book chapters and presentations at national and international Congresses is provided in the CV.
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