Regenera is our main, long-term endeavour, a project designed by prof. Claudio Migliaresi that gathers together several researchers from UNITN’s Department of Industrial Engineering and external collaborators as well.
The main objective of the project is to develop technologies and materials to generate a platform for the design and fabrication of customizable, fully integrable and tissue regenerating biomedical prostheses.
Materials and methods of fabrication of vertebra/intervertebral disc replacements that can osteogenically integrate in the lumbar spine to substitute damaged vertebrae and/or discs will be designed and optimized, while fulfilling the biomechanical requirements and induce regeneration of the tissues considering also patients with osteoporosis.
As specific case study, an innovative total spinal disc/vertebra replacement will be designed, osteointegrable, regenerative, biomechanically tailored, provided with biosensors able to monitor changes in cell–matrix interactions as a function of tissue growth and development and applicable to less invasive surgical procedures. Integrated approaches will be followed and nanotechnologies will be applied to develop surface-modified osteointegrable and wear-resistant surfaces, nanostructured bioactive “smart” gels and nanocomposites.
The research will be validated by the fabrication of demonstrators that will undergo physico-mechanical as well as biological in vitro evaluation, using a market-oriented approach. A major task of the project is also the study of a specific simulator to evaluate in vitro the mechanical performance of the system under physiological like conditions, and the vertebral district regeneration pattern, and the definition of test methods, biological and mechanical testing procedures that could contribute to the setting of standards. The exploited technologies (osteointegrative and wear resistant surface treatments and coatings, regeneration inducing materials, use of cells and growth factors, alloys, nanocomposites, sensing, simulation tests and standards) could also be applied to other sectors of biomedicine and bioengineering.
Regenerative Medicine Innovation Crossing -Research and Innovation Staff Exchange in Regenerative Medicine — REMIX — is a research and mobility project funded by the European Union under the MSCA-RISE instrument, G.A. 778078.
The project’s partners are the University of Trento (Italy – Coordinator), University of Minho (Portugal), Chulalongkorn University (Thailand), Mongolian University of Science and Technology (MUST), Chonbuk National University (South Korea).
The main objective of REMIX is to actively investigate and develop natural or nature-inspired biomaterials for tissue engineering and regeneration therapy through intensive collaboration among European and Asian experts with different academic and scientific backgrounds, aiming at the build-up of a research hub of nature-derived biomaterials for TERM.
More information on REMIX can be found at www.remix-term.eu