Therapeutic treatment of chromatinopathies

Department/Centre: CIBIO - Department of Cellular, Computational and Integrative Biology
Inventors: Alessio Zippo (UniTrento), Alessandra Fasciani (UniTrento).
Field of use: therapeutic treatment of Kabuki syndrome patients; therapeutic treatment of patients affected by other chromatinopathies.
Keywords: chroamtinopathies, rare genetic diseases; Kabuki syndrome; nuclear mechanical stress; ATR.
Bibliographical data: application number:102020000005527(Italian filing); priority date: 16/03/2020
Assignees: Università di Trento
Availability: available for license or assignment

Description

This invention relates to the therapeutic treatment of chromatinopathies, i.e. genetic dis-orders characterized by mutated genes encoding for chromatin regulators, including Kabuki Syn-drome (KS), Kabuki Syndrome 2 (KS 2), Charge Syn-drome (CS), Rubinstein-Taybi syndrome (RT) and Cornelia de Lange syndrome (CdL). 

RNA interference therapy for neurodegenerative diseases

Department/Centre: CIBIO - Department of Cellular, Computational and Integrative Biology
Inventors: Michela Alessandra Denti (UniTrento), Giuseppina Covello (UniTrento), Kavitha Siva (UniTrento)
Fields of use: rare genetic diseases, neurodegenerative diseases 
Keywords: siRNA
Bibliographical data: application number: IB2016/051676 (PTC filing); priority date: 25/3/2015. Patent granted in EU (16712085), US (15/561,208) and Israel (254632)
Assignees: Università di Trento
Availability: available for license or assignment

Description

This invention refers to a therapy mediated by RNA interference for neurodegenerative diseases associated to microtubule-associated protein Tau (Tauopathies).

Method for manufacturing porous scaffolds for biomedical uses and scaffolds thereof

Department/Centre: BIOtech - Center for Biomedical Technologies
Inventors: Devid Maniglio (UniTrento), Walter Bonani (UniTrento)
Fields of use: regeneration of bone tissue
Keywords: porous polymeric scaffolds, tissue engineering, bone tissue regeneration
Bibliographical data: application number: PCT/IB2015/057196; priority date: 25/9/2014; patent granted in Italy
Assignees: Università di Trento
Availability: available for license or assignment

Description

The invention concerns a novel method for manufacturing porous, tridimensional, biomedical, scaffolds starting from a polymer in water dispersion in a single manufacturing step. Right after preparation scaffolds are either ready to be used for cell culture or can undergo to different post processing steps with the aim of improving or modifying the scaffolds properties. 

New therapy for the treatment of tumors

Department/Centre: CIBIO - Department of Cellular, Computational and Integrative Biology
Inventors: Alessandro Quattrone (UniTrento), Ines Mancini (UniTrento), Denise Sighel (UniTrento), Angelika Modelska (UniTrento)
Fields of use: in GBM or other tumors treatment
Keywords: mitochondrial translation inhibition, quinupristin/dalfopristin, drug repurposing, streptogramins A derivatives
Bibliographical data: application number: 102020000012601 (Italian filing); priority date: 27/05/2020
Assignees: Università di Trento; Fondazione Giovanni Celeghin
Availability: available for license or assignment

Description

This invention consists in a new therapy for the treatment of tumors. It concerns a streptogramin A derivative, alone or in combination with quinupristin, for use in the treatment of a tumor (e.g. glioblastoma multiforme, acute myeloid leukemia, chronic myeloid leukemia, epithelial ovarian cancer, ductal adenocarcinoma, melanoma, colorectal, prostate, breast and lung cancer). 

Physiologically compatible artificial cells

Department/Centre: CIBIO - Department of Cellular, Computational and Integrative Biology
Inventors: Sheref Mansy (UniTrento), Marie-Laure Michele Baudet (UniTrento), Luciano Conti (UniTrento), Ömer Duhan Toparlak (UniTrento)
Fields of use: targeted and stimuli-responsive synthesis and release of therapeutics; alteration of host physiology without genetic tools. Intervention of cancer, metabolic, signaling and neurological disorders
Keywords: advanced drug delivery; physiological artificial cells; smart therapeutics; stimuli-responsive liposomes.
Bibliographical data: application number: 102020000021877 (Italian filing); priority date: 16/09/2020
Assignees: Università di Trento
Availability: available for license or assignment

Description

This invention is a genetically-controlled, stimuli-responsive (nano)bioreactor, i.e. artificial cells, that can produce proteins and release cargo materials after synthesizing the therapeutics. The invention is compatible with and/or operates under physiological conditions, can be used as smart drug delivery devices, influence both eukaryotic and bacterial cells within the host organisms.